Statistical Methods for Test and Biomarker Evaluation Studies: A Clinical Chemistry Series

Statistical methods for test and biomarker evaluation studies: a clinical chemistry series.

Studies related to the development and evaluation of biomarkers constitute a major portion of the published work in Clinical Chemistry. In 2011, for example, approximately 70% of original articles considered these topics. Owing to the importance of biomarker evaluation, knowledge of statistical approaches for assessing biomarker data has become increasingly necessary, and the surprisingly high ...

Guide to the use of statistical methods in clinical studies

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Statistical Review and Evaluation CLINICAL STUDIES

Statistical evaluation of a biomarker.

A biomarker may provide a diagnosis, assess disease severity or risk, or guide other clinical interventions such as the use of drugs. Although considerable progress has been made in standardizing the methodology and reporting of randomized trials, less has been accomplished concerning the assessment of biomarkers. Biomarker studies are often presented with poor biostatistics and methodologic fl...

Studies on adrenocortical eosinopenia: a clinical and statistical evaluation of four-hour eosinophil response test.

As early as 1914 Schwarz (1) suspected an inverse relationship between adrenal activity and the level of circulating eosinophils. Twenty-five years later Dalton and Selye (2) noted eosinopenia following stress in animals and related it to release of adrenal cortical hormones. More recently Thorn and his associates (3, 4) observed a prompt decrease in circulating eosinophils in healthy persons, ...